agilent-6490-1260-right-angle-wm
agilent-6490-1260-front-wm

Agilent 6490 Triple Quad LC/MS with 1260 Infinity II HPLC Front End




Includes:

  • Agilent 6490 Triple Quad LC/MS
  • Agilent 1260 Infinity II Front End
    • Solvent Tray
    • 1260 HiP Degasser
    • 1260 Binary Bump
    • 1260 Multisampler
    • 1260 Multicolumn Thermostat (MCT)
  • Mechanical Pump
  • Data System
  • Warranty Coverage

Options:

  • Module Customization
  • MS Sample Introduction
  • Workbench – Browse
  • Installation & Familiarization
  • Extended Warranty
  • Financing Available


15-Day

Refurbishment cadence

OEM-Spec

Verified against OEM and published benchmarks; report included.

On-Staff

Solution Scientists

Since 1996

Three decades supporting labs

The System

What you are buying

A refurbished Agilent 6490 Triple Quadrupole LC/MS with a 1260 Infinity II HPLC front end. The 1260 Infinity II pump and sampler separate the mixture and deliver a reproducible gradient to the source. The 6490’s iFunnel ion source converts the eluent into gas-phase ions with high efficiency. The triple quadrupole isolates a precursor, fragments it, and measures the product ion at trace levels. GenTech rebuilds and tests the LC, the source, and the analyzer, then verifies the system end to end.

Every unit moves through the GenTech Certified process. Solution Scientists disassemble and inspect each module, replace all consumables and degraded wear components, then tune and calibrate the instrument and verify performance against OEM and published benchmarks using known reference chemicals. The instrument ships with its verification report. A certified-refurbished system gives you that performance without the capital cost or the lead time of a new purchase.

What Agilent says about this platform

Agilent built the 6490 around iFunnel technology, combining Jet Stream thermal gradient focusing, a hexabore capillary, and a dual ion funnel to carry more ions from the source into the analyzer. A curved collision cell steers ions away from neutral background noise before they reach the second quadrupole. Agilent reports sensitivity down to the attogram level for well-behaved compounds. MassHunter Workstation software runs acquisition, qualitative analysis, and quantitative analysis.

 

What each module does

Liquid chromatograph

Separates the mixture and delivers a reproducible gradient to the source. The 1260 Infinity II front end runs the same pumps and samplers as a standalone HPLC, rated to 600 bar.

Ion source

Converts the liquid eluent into gas-phase ions. Jet Stream, a hexabore capillary, and a dual ion funnel work together to carry more ions into the analyzer than a conventional source.

Mass analyzer

Two quadrupoles flank a curved collision cell that steers ions away from neutral background noise. The first selects a precursor, the cell fragments it, and the second measures a product ion at trace levels.

Vacuum and detection

Stages the ions from atmosphere to high vacuum, then counts them at the detector.

In this stack
Triple Quadrupole MS G6490A Verified
1260 Infinity II HPLC Front End 1260 Infinity Verified
1260 Multicolumn Thermostat G7116A Verified
1260 Diode Array Detector G7115A Verified
Workstation loaded with software
Included
Specifications

Technical detail

Ion source iFunnel (Jet Stream + dual ion funnel))
Collision cell Curved, off-axis noise rejection
Sensitivity To the attogram level (Agilent-reported)
Software MassHunter
1260 Infinity Front End Agilent HPLC
Max pressure 600 bar (up to 5 mL/min)
Pump options Isocratic, binary, quaternary

*OEM specifications for brand new instrument.

Certification

What “GenTech Certified” means

Refurbishment at GenTech is a defined process, not a wipe-down. Every system moves through the same five stages.

1. Disassembly and rebuild. Solution Scientists strip the instrument down, clean each module inside and out, and rebuild it from the frame up. They replace pump seals, pistons, and check valves to specification.

2. Configuration and new parts. Solution Scientists install the options and modules you selected and fit new wear parts throughout. They replace the detector lamp with a new one and reset the lamp hours.

3. Diagnostic and performance testing. Solution Scientists tune and calibrate the instrument, run system diagnostics, and confirm detector wavelength accuracy. They test full-system pressure and gradient performance against OEM and published benchmarks using known reference chemicals.

4. Data package you approve before shipment. The verification data goes to you for approval before the system leaves the bench. You see exactly how the instrument performs before it ships.

5. Delivery and installation. The instrument ships in protective packing with a one-year warranty option and professional installation available from a GenTech Solution Scientist.

Application Fit

Labs that run this system

The 6490 is method-compatible across the techniques most regulated and research labs run every day. These are the application areas buyers ask about most.

Environmental

PFAS testing

EPA Method 537.1 and similar state programs require quantitation of per- and polyfluoroalkyl substances in drinking water at low parts-per-trillion levels, a sensitivity range triple quadrupole MS is built to reach.

Food & Beverage / Cannabis

Pesticides and mycotoxins

Multi-residue pesticide panels and mycotoxin screens in food and cannabis testing often cover more than 100 compounds in a single run, each requiring the selectivity a triple quadrupole provides against a complex matrix background.

Pharmaceutical

Trace impurities and cleaning validation

Pharmaceutical cleaning validation protocols confirm that equipment surfaces carry no detectable residue of the previous product, often down to sub-part-per-billion swab or rinse limits.

Clinical & Forensic

Quantitative toxicology

Forensic and clinical toxicology panels quantify drugs and metabolites in blood, urine, or tissue against legally defensible limits, where a triple quadrupole’s selectivity rules out false positives from matrix interferences.

Regulated Bioanalysis

GLP-grade quantitation

Good Laboratory Practice studies require documented, audit-ready quantitation with full method validation, a standard regulated bioanalysis labs run routinely on triple quadrupole platforms.

OEM

Agilent Technologies

Model

6490, 1260

Condition

Refurbished

Financing

Financing Options Available

Financing Options Available.  Finance Builder.

Need a main board instead?

Replacing a failed pump or looking to upgrade your mass spec? Every module in this system is available individually, in stock and performance-verified.